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Cat. No.: HY-180780

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G1167

G1167 is an IRE1 ligand, which can be used for the synthesis of PROTACs, such as G6374 (HY-180787).

For research use only. We do not sell to patients.

Formula: C₁₈H₂₇N₅O
Molecular Weight:329.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

G1167 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

G1167 is an IRE1 ligand, which can be used for the synthesis of PROTACs, such as G6374 (HY-180787)^[1].

Chemical Information

Molecular Weight 329.44
Formula C₁₈H₂₇N₅O
SMILES

CC(N1C(C=CC2=C1N=C(N=C2)N[C@H]3CC[C@@H](CC3)N(C)C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du J, et al. Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera. Nat Commun. 2025 Dec 11;16(1):11445. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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