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FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

Also Known as SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2268

About FGR

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,612,064-27,635,185 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 32 paralogues. Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues.

Summary

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 Integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

FGR Products (3)

mRNA	Protein	Name
NM_001042729.2	NP_001036194.1	tyrosine-protein kinase Fgr
NM_001042747.2	NP_001036212.1	tyrosine-protein kinase Fgr
NM_005248.3	NP_005239.1	tyrosine-protein kinase Fgr

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Fc-gamma receptor I complex binding	IDA IDA: Inferred from direct assay	8327512	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8327512	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	10861086	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7519620	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	7519620	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7519620	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	10739672	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	2181286	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cytoskeleton	IDA IDA: Inferred from direct assay	8603737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGR Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

FGR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FGR	P09769	MET	Homo sapiens	P08581	FPS	24728074
Intra	FGR	P09769	KIT	Homo sapiens	P10721	FPS	24728074
Intra	FGR	P09769	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	FGR	P09769	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	FGR	P09769	AR	Homo sapiens	P10275	FPS	24728074
Intra	FGR	P09769	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	FGR	P09769	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872

Cross: Cross-species interaction Intra: Intraspecies interaction

FGR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84035	FGR Antibody (YA3732)	WB, IHC-P, ELISA	Human, Mouse
HY-P84035A	FGR Antibody (YA3732)(PBS only)	WB, IHC-P, ELISA	Human, Mouse
HY-P85100	FGR Antibody (YA4792)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Placental Insufficiency	Uteroplacental Vascular Insufficiency
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Cd45 Deficiency
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Oligohydramnios	Oligohydramnios - Delivered Antepartum Oligohydramnios Delivered Oligohydramnios Oligohydramnios, Antepartum Condition Or Complication Deficient Liquor Oligohydramnios, Unspecified Trimester Reduced Liquor Volume
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FGR	VGNC	VGNC:40866
Bos taurus	FGR	VGNC	VGNC:28994
Mus musculus	FGR	MGD	MGI:95527
Rattus norvegicus	FGR	RGD	RGD:621319
Macaca mulatta	FGR	VGNC	VGNC:72658
Felis catus	FGR	VGNC	VGNC:62262
Others	FGR	NCBI