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Cat. No.: HY-183424

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Hydrolapachol

Hydrolapachol is a mitochondrial respiratory chain inhibitor that targets the site between cytochrome b and c₁, and inhibits succinate oxidation in rat liver mitochondria. Hydrolapachol can be used in studies related to mitochondrial respiration.

For research use only. We do not sell to patients.

CAS No.: 3343-38-2
Formula: C₁₅H₁₆O₃
Molecular Weight:244.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hydrolapachol Chemical Structure

CAS No.: 3343-38-2

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Hydrolapachol inhibits succinate oxidation in intact rat liver mitochondria with an IC₅₀ of 1.6 μg per mg protein^[1].
Hydrolapachol exerts a stronger inhibitory effect on succinate oxidation in intact rat liver mitochondria at lower pH, and this inhibition is completely reversed by bovine serum albumin, CCCP (HY-100941) and 2,4-dibromophenol, and partially reversed by 2,4-dinitrophenol; at low inhibitor concentrations, phosphate (or arsenate) is required to achieve maximal inhibition of succinate oxidation in intact rat liver mitochondria^[1].
Hydrolapachol can be prepared by platinum oxide-platinum black-catalyzed hydrogenation of Isolapachol, and can also be obtained by hydrogenation of lapachol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3343-38-2
Molecular Weight 244.29
Formula C₁₅H₁₆O₃
SMILES

O=C1C(O)=C(CCC(C)C)C(C2=C1C=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Howland JL. Inhibition of mitochondrial succinate oxidation by alkyl hydroxy naphthoquinones. Biochim Biophys Acta. 1965 Aug 24;105(2):205-13. [Content Brief]

[2]. Hooker SC. Condensation of Aldehydes with β-Hydroxy-α-naphthoquinone. Synthesis of Hydrolapachol. J Am Chem Soc. 1936;58(7):1163-1167.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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