PK-3
PK-3 is a cancer cell growth inhibitor with microtubule-binding activity. PK-3 binds to tubulin, disrupts the intracellular microtubule network required for mitosis, and induces cell death. PK-3 can be used in research related to chronic myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 932331-38-9
- Formula: C21H20N2O3S
- Molecular Weight:380.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.049 μM
Compound: 1
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 27423028] |
| HepG2 | IC50 |
0.029 μM
Compound: 1
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Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
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[PMID: 27423028] |
| HT-1080 | EC50 |
<100 nM
Compound: 3, CID 20959075
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Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay
Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay
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[PMID: 22247791] |
| MCF-10A | EC50 |
<100 nM
Compound: 3, CID 20959075
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Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay
Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay
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[PMID: 22247791] |
| PC-3 | IC50 |
0.038 μM
Compound: 1
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
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[PMID: 27423028] |
| SK-OV-3 | IC50 |
0.047 μM
Compound: 1
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Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
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[PMID: 27423028] |
PK-3 (18-55 nM; 10 to 21 days) induces a form of non-apoptotic cell death that is distinct from ferroptosis in KBM7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human chronic myeloid leukemia KBM7 cells
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Concentration:55 nM (initial screening for colony outgrowth); 18 nM (final estimated after 3-day initial incubation with growth medium dilution)
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Incubation Time:10 to 21 days
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Result:Induced a non-ferroptotic form of non-apoptotic cell death in KBM7 cells.
Yielded no significantly enriched genes with gene trap insertions in PK-3-resistant KBM7 colonies.
Chemical Information
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CAS No. 932331-38-9
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Molecular Weight 380.46
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Formula C21H20N2O3S
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SMILES
O=S(N1CCCC2=C1C=CC=C2)(C3=CC=C(C=C3)C4=CN=C(O4)C5CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PK-3 Related Classifications
HY-119126 Related Classifications
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