(S)-DMAPT
(S)-DMAPT ((S)-Dimethylamino Parthenolide) is a sesquiterpene lactone with radioprotective and radiation-mitigating effects. (S)-DMAPT alleviates radiation-induced bladder fibrosis and fibrosis markers in the lungs and bladder. (S)-DMAPT alleviates radiation-induced oligospermia, colorectal tissue senescence, and testicular senescence. (S)-DMAPT prevents radiation-induced skin damage.
For research use only. We do not sell to patients.
- CAS No.: 870677-05-7
- Formula: C17H27NO3
- Molecular Weight:293.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
(S)-DMAPT (thrice weekly every week; from one week pre-irradiation to study endpoint) reduces radiation-induced SA-β-Gal senescence in colorectal tissue and testis of C57BL/6J mice[1].
(S)-DMAPT (on the day of irradiation; once a day for the subsequent three days) reduces lung and bladder RNA expression of the ARS/fibrosis biomarkers Wnt3 and Ddb2 after high-dose whole-body irradiation in C57BL/6J mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 870677-05-7
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Molecular Weight 293.40
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Formula C17H27NO3
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SMILES
C[C@]12[C@@](O2)([H])[C@]3([H])[C@](CC/C(C)=C\CC1)([H])[C@H](C(O3)=O)CN(C)C
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Synonyms
(S)-Dimethylamino Parthenolide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-DMAPT Related Classifications
HY-16172A Related Classifications
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Keywords
- (S)-DMAPT
- 870677-05-7
- (S)-Dimethylamino Parthenolide
- Drug Isomer
- bladder fibrosis
- colorectal tissue senescence
- lung fibrosis
- radiation-induced fibrosis
- radiation-induced hypospermia
- radiation-induced skin injury
- radiomitigative
- radioprotective
- sesquiterpene lactone inhibitor
- testicular senescence
- Inhibitor
- inhibitor
- inhibit