2′-Thioadenosine
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site.
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- CAS 番号: 136904-69-3
- 分子式: C10H13N5O3S
- 分子量:283.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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ErbB1 |
ErbB2 45 μM (IC50) |
2'-Thioadenosine (50 µM) exhibits no activity against FGF, PDGF orinsulin receptor tyrosine kinases[1].
2'-Thioadenosine covalently inactivates ErbB-1, which is reversed by 1 mM Dithiothreitol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 136904-69-3
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分子量 283.31
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分子式 C10H13N5O3S
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SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
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別名
PD157432
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
2′-Thioadenosine 関連分類
HY-137028 関連分類
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