4-Hydroxyatomoxetine
Based on 1 Customer Validation
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.04%
- CAS 番号: 435293-66-6
- 分子式: C17H21NO2
- 分子量:271.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1490 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
164 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
88 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
>5000 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
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[PMID: 15225731] |
化学情報
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CAS 番号 435293-66-6
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性状 Solid
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分子量 271.35
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分子式 C17H21NO2
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Color Off-white to yellow
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SMILES
OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (460.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.
[2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6853 mL | 18.4264 mL | 36.8528 mL | 92.1319 mL |
| 5 mM | 0.7371 mL | 3.6853 mL | 7.3706 mL | 18.4264 mL | |
| 10 mM | 0.3685 mL | 1.8426 mL | 3.6853 mL | 9.2132 mL | |
| 15 mM | 0.2457 mL | 1.2284 mL | 2.4569 mL | 6.1421 mL | |
| 20 mM | 0.1843 mL | 0.9213 mL | 1.8426 mL | 4.6066 mL | |
| 25 mM | 0.1474 mL | 0.7371 mL | 1.4741 mL | 3.6853 mL | |
| 30 mM | 0.1228 mL | 0.6142 mL | 1.2284 mL | 3.0711 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9213 mL | 2.3033 mL | |
| 50 mM | 0.0737 mL | 0.3685 mL | 0.7371 mL | 1.8426 mL | |
| 60 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 80 mM | 0.0461 mL | 0.2303 mL | 0.4607 mL | 1.1516 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL |
4-Hydroxyatomoxetine 関連分類
HY-133116 関連分類
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