4-Hydroxytolbutamide
Based on 1 Customer Validation
4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.69%
- CAS 番号: 5719-85-7
- 分子式: C12H18N2O4S
- 分子量:286.35
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Potassium channel
化学情報
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CAS 番号 5719-85-7
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性状 Solid
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分子量 286.35
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分子式 C12H18N2O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O
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別名
Hydroxytolbutamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (436.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (545 KB)
- English - EN (545 KB)
- Français - FR (545 KB)
- Deutsch - DE (545 KB)
- Norwegian - NO (545 KB)
- Español - ES (545 KB)
- Swedish - SV (545 KB)
- Italian - IT (545 KB)
- Korean - KR (545 KB)
- Portuguese - PT (545 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [Content Brief]
[2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4922 mL | 17.4611 mL | 34.9223 mL | 87.3057 mL |
| 5 mM | 0.6984 mL | 3.4922 mL | 6.9845 mL | 17.4611 mL | |
| 10 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL | 8.7306 mL | |
| 15 mM | 0.2328 mL | 1.1641 mL | 2.3282 mL | 5.8204 mL | |
| 20 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL | 4.3653 mL | |
| 25 mM | 0.1397 mL | 0.6984 mL | 1.3969 mL | 3.4922 mL | |
| 30 mM | 0.1164 mL | 0.5820 mL | 1.1641 mL | 2.9102 mL | |
| 40 mM | 0.0873 mL | 0.4365 mL | 0.8731 mL | 2.1826 mL | |
| 50 mM | 0.0698 mL | 0.3492 mL | 0.6984 mL | 1.7461 mL | |
| 60 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4551 mL | |
| 80 mM | 0.0437 mL | 0.2183 mL | 0.4365 mL | 1.0913 mL | |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL |
4-Hydroxytolbutamide 関連分類
HY-100641 関連分類
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