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製品番号: HY-181703

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4-PSQ

4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na⁺, K⁺-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1415931-33-7
分子式: C₁₅H₁₀ClNSe
分子量:318.66

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

4-PSQ 構造式

CAS 番号: 1415931-33-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

体内実験

4-PSQ (1 mg/kg; p.o.; daily; 10 days) reverses Vincristine (HY-N0488A)-induced impairments in cognitive, depression-like and anxiety-like behaviors in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice with Vincristine (VCR)-induced neurotoxicity (male and female, 60 days old)^[1]
Dosage:

1 mg/kg
Administration:

p.o.; daily; days 7 to 16
Result:

Restored short-term and long-term memory impairments induced by vincristine in both sexes.
Normalized depressive-like behavior in both sexes.
Reversed anxiety-like behavior in both sexes.
Counteracted vincristine-induced inhibition of Na⁺,K⁺-ATPase activity in the cerebral cortex, spinal cord, and cerebellum of male mice, and in the cerebellum of female mice.
Normalized vincristine-induced increased p21 mRNA expression in the cerebral cortex of female mice.
Normalized vincristine-induced increased NFκB mRNA expression in the cerebral cortex of male mice, and in the spinal cord of male and female mice.

Related Protocols :

化学情報

CAS 番号 1415931-33-7
分子量 318.66
分子式 C₁₅H₁₀ClNSe
SMILES

ClC1=CC=C2C([Se]C3=CC=CC=C3)=CC=NC2=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. da Motta KP, et al. Correlation between NFκB Signaling and Na+, K+‑ATPase Inhibition in Vincristine-Induced Emotional and Cognitive Comorbidities in Mice: Neuroprotective Potential of 4‑PSQ. ACS Omega. 2026 Feb 9;11(7):11219-11232. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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