8-Demethyleucalyptin
8-Demethyleucalyptin is a natural flavonoid.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 5689-38-3
- 分子式: C18H16O5
- 分子量:312.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
体外実験
8-Demethyleucalyptin (Compound C2) exhibits bacteriostatic activity against MSSA ATCC 25923 and MRSA ATCC 33591 with MIC of 31.25 μg/mL and 62.5 μg/mL[1].
8-Demethyleucalyptin (15.625-31.25 μg/mL; 48 h) inhibits biofilm formation of MRSA and MSSA with inhibition rate of 31.6% and 37.1%[1].
8-Demethyleucalyptin (15.625-31.25 μg/mL; 48 h) weakly inhibits staphyloxanthin biosynthesis of MRSA and MSSA with inhibition rate of 14.2% and 22.2% and reduces acid tolerance[1].
8-Demethyleucalyptin (31.25-62.5 μg/mL; 18 h) disrupts cell membrane and wall integrity in MSSA and MRSA[1].
8-Demethyleucalyptin (48-72 h) inhibits HCT116 and MRC-5 cells viability (IC50 = 6.4 and 7.0 μM and IC50 >100 μM for Jurkat cells)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 5689-38-3
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分子量 312.32
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分子式 C18H16O5
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SMILES
O=C1C=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=C(C)C(OC)=C3
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Shehabeldine AM, et al. Callistemon citrinus bioactive metabolites as new inhibitors of methicillin-resistant Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2020;254:112669. [Content Brief]
[2]. Asakawa R, et al. Synthesis and cytotoxic activities of 8- and 6-demethyleucalyptins. Biosci Biotechnol Biochem. 2022;86(9):1200-1206. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)