8-Nitro-cGMP
8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice.
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- CAS 番号: 913645-39-3
- 分子式: C10H11N6O9P
- 分子量:390.20
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保管条件:
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生物活性
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化学情報
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生物活性
製品説明
化学情報
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CAS 番号 913645-39-3
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分子量 390.20
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分子式 C10H11N6O9P
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SMILES
O=C1C2=C(N([C@@H]3O[C@H](CO4)[C@@H](OP4(O)=O)[C@H]3O)C([N+]([O-])=O)=N2)NC(N)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ihara H, et al. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 2017 Sep 18;30(9):1673-1684. [Content Brief]
[2]. Tokutomi Y, et al. Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice. Br J Pharmacol. 2011 Apr;162(8):1884-93. [Content Brief]
[3]. Kaneko K, et al. 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. Nitric Oxide. 2018 Jan 30;72:46-51. [Content Brief]
[4]. Rawet-Slobodkin M, Elazar Z. 8-nitro-cGMP--a new player in antibacterial autophagy. Mol Cell. 2013 Dec 26;52(6):767-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
8-Nitro-cGMP 関連分類
HY-134314 関連分類
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