9-Hydroxycalabaxanthone
Based on 1 Customer Validation
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.14%
- CAS 番号: 35349-68-9
- 分子式: C24H24O6
- 分子量:408.44
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Parasite アイソフォーム固有の製品をすべて表示
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生物活性
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | IC50 |
25.49 μM
Compound: 12a
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Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
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[PMID: 24717154] |
| B16-F10 | IC50 |
26.17 μM
Compound: 12a
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Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
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[PMID: 24717154] |
| HeLa S3 | IC50 |
1.9 μM
Compound: 26
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Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| HepG2 | IC50 |
3.4 μM
Compound: 26
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Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| HT-29 | ED50 |
9.1 μM
Compound: 8
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 19839614] |
| HT-29 | IC50 |
1.6 μM
Compound: 26
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Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
|
[PMID: 30978023] |
| KB | IC50 |
1.7 μM
Compound: 26
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Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| MCF7 | IC50 |
1.9 μM
Compound: 26
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Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| MCF7 | IC50 |
3.9 μg/mL
Compound: 5
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Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
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[PMID: 19296616] |
| MDA-MB-231 | IC50 |
21.06 μM
Compound: 12a
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Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
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[PMID: 24717154] |
| NCI-H460 | IC50 |
19.69 μM
Compound: 12a
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Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
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[PMID: 24717154] |
| RAW264.7 | IC50 |
18.6 μM
Compound: 8
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Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
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[PMID: 31860303] |
| SW-620 | IC50 |
26.14 μM
Compound: 12a
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Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
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[PMID: 24717154] |
9-Hydroxycalabaxanthone inhibits the activities of 3D7 and K1 P. falciparum clones with IC50 values of 1.5 μM and 1.2 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 35349-68-9
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性状 Solid
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分子量 408.44
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分子式 C24H24O6
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Color Light yellow to yellow
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SMILES
O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C4C(C=CC(C)(C)O4)=C2O
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別名
Xanthone I
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 50 mg/mL (122.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gamal A Mohamed, et al. Mangostanaxanthones I and II, New Xanthones From the Pericarp of Garcinia Mangostana. Fitoterapia. 2014 Oct;98:215-21. [Content Brief]
[2]. Wanna Chaijaroenkul, et al. The in Vitro Antimalarial Interaction of 9-hydroxycalabaxanthone and α-mangostin With mefloquine/artesunate. Acta Parasitol. 2014 Mar;60(1):105-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4483 mL | 12.2417 mL | 24.4834 mL | 61.2085 mL |
| 5 mM | 0.4897 mL | 2.4483 mL | 4.8967 mL | 12.2417 mL | |
| 10 mM | 0.2448 mL | 1.2242 mL | 2.4483 mL | 6.1209 mL | |
| 15 mM | 0.1632 mL | 0.8161 mL | 1.6322 mL | 4.0806 mL | |
| 20 mM | 0.1224 mL | 0.6121 mL | 1.2242 mL | 3.0604 mL | |
| 25 mM | 0.0979 mL | 0.4897 mL | 0.9793 mL | 2.4483 mL | |
| 30 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 40 mM | 0.0612 mL | 0.3060 mL | 0.6121 mL | 1.5302 mL | |
| 50 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL | |
| 60 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0201 mL | |
| 80 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7651 mL | |
| 100 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6121 mL |
9-Hydroxycalabaxanthone 関連分類
HY-N2795 関連分類
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