ABBV-4083
ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1809266-03-2
- 分子式: C53H82FNO17
- 分子量:1024.21
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1].
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Dosage:150 mg/kg.
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Administration:PO once daily for 14 days started at 14 weeks post infection (pti).
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Result:Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1809266-03-2
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性状 Solid
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分子量 1024.21
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分子式 C53H82FNO17
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](C)O[C@](OC[C@H]([C@@H](CC)OC(C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]2C)O[C@]3([H])O[C@H](C)[C@@H](O[C@]4([H])O[C@@H](C)[C@H](OCC5=CC=C(F)C=C5)[C@@](O)(C)C4)[C@H](N(C)C)[C@H]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[C@H](OC)[C@@H]1OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (97.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9764 mL | 4.8818 mL | 9.7636 mL | 24.4091 mL |
| 5 mM | 0.1953 mL | 0.9764 mL | 1.9527 mL | 4.8818 mL | |
| 10 mM | 0.0976 mL | 0.4882 mL | 0.9764 mL | 2.4409 mL | |
| 15 mM | 0.0651 mL | 0.3255 mL | 0.6509 mL | 1.6273 mL | |
| 20 mM | 0.0488 mL | 0.2441 mL | 0.4882 mL | 1.2205 mL | |
| 25 mM | 0.0391 mL | 0.1953 mL | 0.3905 mL | 0.9764 mL | |
| 30 mM | 0.0325 mL | 0.1627 mL | 0.3255 mL | 0.8136 mL | |
| 40 mM | 0.0244 mL | 0.1220 mL | 0.2441 mL | 0.6102 mL | |
| 50 mM | 0.0195 mL | 0.0976 mL | 0.1953 mL | 0.4882 mL | |
| 60 mM | 0.0163 mL | 0.0814 mL | 0.1627 mL | 0.4068 mL | |
| 80 mM | 0.0122 mL | 0.0610 mL | 0.1220 mL | 0.3051 mL |
ABBV-4083 関連分類
HY-111757 関連分類
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