Altretamine
Based on 4 publication(s) in Google Scholar
Altretamine is an alkylating antineoplastic agent.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 645-05-6
- 分子式: C9H18N6
- 分子量:210.28
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Altretamine
More
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | GI50 |
>10 mM
Compound: 3j
|
Photocytotoxicity against human HL60 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human HL60 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
| HL-60 | GI50 |
7.2 mM
Compound: 3j
|
Photocytotoxicity against human HL60 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human HL60 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
| LoVo | GI50 |
10.3 mM
Compound: 3j
|
Photocytotoxicity against human LoVo cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
| LoVo | GI50 |
17.2 mM
Compound: 3j
|
Photocytotoxicity against human LoVo cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
| NCTC-2544 | GI50 |
>20 mM
Compound: 3j
|
Photocytotoxicity against human NCTC-2544 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human NCTC-2544 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
| NCTC-2544 | GI50 |
7.5 mM
Compound: 3j
|
Photocytotoxicity against human NCTC-2544 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human NCTC-2544 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
|
[PMID: 17449247] |
Altretamine is an antineoplastic agent[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 645-05-6
-
性状 Solid
-
分子量 210.28
-
分子式 C9H18N6
-
Color White to off-white
-
SMILES
CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1
-
別名
アルトレタミン; ENT-50852; RB-1515; WR-95704
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep Med
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]2025 Apr 15;6(4):102053. PMID: 40187357 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
溶剤 & 溶解度
DMSO : 8.33 mg/mL (39.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
プロトコル
Mice[1]
Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7556 mL | 23.7778 mL | 47.5556 mL | 118.8891 mL |
| 5 mM | 0.9511 mL | 4.7556 mL | 9.5111 mL | 23.7778 mL | |
| 10 mM | 0.4756 mL | 2.3778 mL | 4.7556 mL | 11.8889 mL | |
| 15 mM | 0.3170 mL | 1.5852 mL | 3.1704 mL | 7.9259 mL | |
| 20 mM | 0.2378 mL | 1.1889 mL | 2.3778 mL | 5.9445 mL | |
| 25 mM | 0.1902 mL | 0.9511 mL | 1.9022 mL | 4.7556 mL | |
| 30 mM | 0.1585 mL | 0.7926 mL | 1.5852 mL | 3.9630 mL |
Altretamine 関連分類
HY-B0181 関連分類
Powered by Bioz