BCA
Based on 8 publication(s) in Google Scholar
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.99%
- CAS 番号: 979-88-4
- 分子式: C20H10N2Na2O4
- 分子量:388.28
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 BCA
More- Adv Funct Mater. 2024 Mar 14.
- Cardiovasc Diabetol. 2019 Feb 2;18(1):15. [Abstract]
- Mater Today Bio. 2025 Feb 20:31:101598. [Abstract]
- Nano Today. 2025 Jun.
- Nano Today. 2025 Jun.
- Biologics. 2024 May 23:18:129-142. [Abstract]
- J Cancer. 2021 Feb 22;12(8):2243-2257. [Abstract]
- J Oncol. 2022 Aug 11;2022:5824617. [Abstract]
生物活性
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BACE1 28 μM (IC50) |
BACE1 43 μM (Ki) |
BCA (20, 40 mg/kg; p.o.; daily for 90 days) reduces the reduction of mitochondrial biogenesis, imbalances of mitochondrial dynamics, and abnormal mitophagy caused by ovariectomy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old female athymic nude mice[1]
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Dosage:5, 15 mg/kg
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Administration:I.p.; daily
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Result:Reduced the incidence and the growth of estrogen-dependent MCF-7 tumors in a breast cancer xenograft mouse model.
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Animal Model:APP/PS1 mice underwent bilateral ovariectomy[2]
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Dosage:20, 40 mg/kg
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Administration:P.o.; daily for 90 days
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Result:Rescued the reduction of mitochondrial biogenesis, imbalanced of mitochondrial dynamics, and abnormal mitophagy caused by ovariectomy.
化学情報
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CAS 番号 979-88-4
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性状 Solid
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分子量 388.28
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分子式 C20H10N2Na2O4
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Color White to light yellow
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SMILES
O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
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別名
Disodium bicinchoninate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (8)
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Journal Impact Factor
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Most Recent
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Cardiovasc Diabetol
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart. [Abstract]2019 Feb 2;18(1):15. PMID: 30710997 -
Mater Today Bio
A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy. [Abstract]2025 Feb 20:31:101598. PMID: 40070867 -
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Biologics
LncRNA GAS5 Modulates the Progression of Glioma Through Repressing miR-135b-5p and Upregulating APC. [Abstract]2024 May 23:18:129-142. PMID: 38817552 -
J Cancer
MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma. [Abstract]2021 Feb 22;12(8):2243-2257. PMID: 33758602 -
J Oncol
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway. [Abstract]2022 Aug 11;2022:5824617. PMID: 36226249
溶剤 & 溶解度
H2O : 100 mg/mL (257.55 mM; Need ultrasonic)
7.5% Sodium bicarbonate : ≥ 50 mg/mL (128.77 mM)
DMSO : 2 mg/mL (5.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (64.39 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25(9):2158-63. [Content Brief]
[2]. Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056. [Content Brief]
[3]. Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8(10):637. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 7.5% Sodium bicarbonate / H2O | 1 mM | 2.5755 mL | 12.8773 mL | 25.7546 mL | 64.3865 mL |
| 5 mM | 0.5151 mL | 2.5755 mL | 5.1509 mL | 12.8773 mL | |
| 7.5% Sodium bicarbonate / H2O | 10 mM | 0.2575 mL | 1.2877 mL | 2.5755 mL | 6.4387 mL |
| 15 mM | 0.1717 mL | 0.8585 mL | 1.7170 mL | 4.2924 mL | |
| 20 mM | 0.1288 mL | 0.6439 mL | 1.2877 mL | 3.2193 mL | |
| 25 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5755 mL | |
| 30 mM | 0.0858 mL | 0.4292 mL | 0.8585 mL | 2.1462 mL | |
| 40 mM | 0.0644 mL | 0.3219 mL | 0.6439 mL | 1.6097 mL | |
| 50 mM | 0.0515 mL | 0.2575 mL | 0.5151 mL | 1.2877 mL | |
| 60 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0731 mL | |
| 80 mM | 0.0322 mL | 0.1610 mL | 0.3219 mL | 0.8048 mL | |
| 100 mM | 0.0258 mL | 0.1288 mL | 0.2575 mL | 0.6439 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BCA 関連分類
HY-15908 関連分類
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