BIBF 1202
Based on 1 publication(s) in Google Scholar
BIBF 1202 is the carboxylate metabolite of Nintedanib (HY-50904) which inhibits VEGFR2 kinase with an IC50 of 62 nM.
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- 純度: 99.82%
- CAS 番号: 894783-71-2
- 分子式: C30H31N5O4
- 分子量:525.60
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 BIBF 1202
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生物活性
IC50: 62 nM (VEGFR2)[1]
The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Subsequently, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acylglucuronide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 894783-71-2
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性状 Solid
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分子量 525.60
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分子式 C30H31N5O4
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : ≥ 45 mg/mL (85.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68(12):4774-82. [Content Brief]
[2]. Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41(4):297-311. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9026 mL | 9.5129 mL | 19.0259 mL | 47.5647 mL |
| 5 mM | 0.3805 mL | 1.9026 mL | 3.8052 mL | 9.5129 mL | |
| 10 mM | 0.1903 mL | 0.9513 mL | 1.9026 mL | 4.7565 mL | |
| 15 mM | 0.1268 mL | 0.6342 mL | 1.2684 mL | 3.1710 mL | |
| 20 mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 2.3782 mL | |
| 25 mM | 0.0761 mL | 0.3805 mL | 0.7610 mL | 1.9026 mL | |
| 30 mM | 0.0634 mL | 0.3171 mL | 0.6342 mL | 1.5855 mL | |
| 40 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1891 mL | |
| 50 mM | 0.0381 mL | 0.1903 mL | 0.3805 mL | 0.9513 mL | |
| 60 mM | 0.0317 mL | 0.1585 mL | 0.3171 mL | 0.7927 mL | |
| 80 mM | 0.0238 mL | 0.1189 mL | 0.2378 mL | 0.5946 mL |
BIBF 1202 関連分類
HY-15992 関連分類
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