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製品番号: HY-U00224

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BRL44385

BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 114778-60-8
分子式: C₈H₁₁N₅O₃
分子量:225.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BRL44385 構造式

CAS 番号: 114778-60-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

IC₅₀ & Target

^[1]

HSV-1

HSV-2

HSV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	IC₅₀	0.71 μM Compound: 8, BRL-44385	Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 2 (HSV-2) in MRC-5 cells. Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 2 (HSV-2) in MRC-5 cells.	[PMID: 2153202]
MRC5	IC₅₀	4.4 μM Compound: 8, BRL-44385	Antiviral activity in plaque reduction assay was determined against varicella zoster virus (VZV) in MRC-5 cells. Antiviral activity in plaque reduction assay was determined against varicella zoster virus (VZV) in MRC-5 cells.	[PMID: 2153202]
Vero	IC₅₀	2.1 μM Compound: 8, BRL-44385	Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 1 (HSV-1) in Vero cells. Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 1 (HSV-1) in Vero cells.	[PMID: 2153202]

体内実験

BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides high and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavailability of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 114778-60-8
分子量 225.20
分子式 C₈H₁₁N₅O₃
SMILES

O=C1N=C(N)NC2=C1N=CN2OCCCO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. M. R. Harnden, et al. Synthesis, oral bioavailability and in vivo activity of acetal derivatives of the selective antiherpesvirus agent 9-(3-hydroxypropoxy) guanine (SRL 44385). Antiviral Chemistry & Chemotherapy (1994) 5(3), 147-154.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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