Dencichine
Based on 1 Customer Validation
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.59%
- CAS 番号: 5302-45-4
- 分子式: C5H8N2O5
- 分子量:176.13
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-13426
RoxadustatHIF-PH Inhibitor -
HY-12654
MolidustatHypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor -
HY-101023
MK-8617HIF PHD1-3 Inhibitor -
HY-12832
JNJ-42041935PHD Inhibitor -
HY-101277
VadadustatHIF PH Inhibitor -
HY-15468
IOX2HIF/HIF Prolyl-Hydroxylase Inhibitor -
HY-120110
IOX4PHD2 Inhibitor -
HY-109057
Enarodustat -
HY-12867
PT-2385HIF-2α Inhibitor -
HY-N0293
PaeoniflorinHSP Activator -
HY-18777
KC7F2HIF/HIF Prolyl-Hydroxylase Inhibitor -
HY-12754
ML228HIF Activator
生物活性
製品説明
IC50 & Target
PHD-2[1]
体外実験
Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2[1]. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 5302-45-4
-
性状 Solid
-
分子量 176.13
-
分子式 C5H8N2O5
-
Color White to off-white
-
SMILES
N[C@@H](CNC(C(O)=O)=O)C(O)=O
-
別名
Dencichin; ODAP
-
Structure Classification
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 5 mg/mL (28.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (28.39 mM; Need ultrasonic)
0.1 M HCl : 3.33 mg/mL (18.91 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Eslavath RK, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411. [Content Brief]
[2]. Jie L, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M HCl / DMSO / H2O | 1 mM | 5.6776 mL | 28.3881 mL | 56.7762 mL | 141.9406 mL |
| 5 mM | 1.1355 mL | 5.6776 mL | 11.3552 mL | 28.3881 mL | |
| 10 mM | 0.5678 mL | 2.8388 mL | 5.6776 mL | 14.1941 mL | |
| 15 mM | 0.3785 mL | 1.8925 mL | 3.7851 mL | 9.4627 mL | |
| DMSO / H2O | 20 mM | 0.2839 mL | 1.4194 mL | 2.8388 mL | 7.0970 mL |
| 25 mM | 0.2271 mL | 1.1355 mL | 2.2710 mL | 5.6776 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dencichine 関連分類
HY-N1477 関連分類
Powered by Bioz