GNE-955
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1527523-39-2
- 分子式: C22H24N8O
- 分子量:416.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PIM1 0.018 nM (Ki) |
PIM2 0.11 nM (Ki) |
PIM3 0.08 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | IC50 |
0.5 μM
Compound: 20
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Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Glo assay
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[PMID: 28445037] |
体外実験
GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment[1].
GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1527523-39-2
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分子量 416.48
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分子式 C22H24N8O
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SMILES
CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=N4)C=N2)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GNE-955 関連分類
HY-101783 関連分類
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