L-カルノシン
Based on 3 publication(s) in Google Scholar
L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 305-84-0
- 分子式: C9H14N4O3
- 分子量:226.24
-
保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Clinical Compound Library
HY-L026
-
Human Endogenous Metabolite Compound Library
HY-L030
-
Drug Repurposing Compound Library
HY-L035
-
Antioxidant Compound Library
HY-L037
-
Anti-COVID-19 Compound Library
HY-L052
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
Neuroprotective Compound Library
HY-L070
-
Gut Microbial Metabolite Library
HY-L078
-
Microbial Metabolite Library
HY-L084
-
Peptide Library
HY-L105
-
Anti-inflammatory Traditional Chinese Medicine Active Compound Library
HY-L114
-
Human Metabolite Library
HY-L123
-
Anti-Aging Natural Product Library
HY-L134
-
Animal-Sourced Natural Product Library
HY-L157
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Peptide Compound Library
HY-L105S
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
Anti-Fibrosis Compound Library
HY-L185
-
Miao Ethnicity Medicine Compound Library
HY-L190
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Mass Spectrometry Human Endogenous Metabolite Library
HY-L207
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Mouse Metabolite Compound Library
HY-L217
-
Cosmetic Ingredient Compound Library
HY-L221
-
Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library
HY-L223
-
Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
-
Amino Acid Metabolite Compound Library
HY-L227
-
Mongolian Medicine Compound Library
HY-L238
-
Mass Spectrometry Natural Product Library
HY-L262
-
MCE Kinase Hinge Binder Fragment Library
HY-L907
MedChemExpress（MCE）の使用を引用している文献 L-Carnosine
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
|
Human Endogenous Metabolite |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
28 μM
Compound: 439224
|
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
|
10.5281/zenodo.7360449 |
| HEK293 | EC50 |
28 μM
Compound: 439224
|
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells (PubChem AID: 1794819)
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells (PubChem AID: 1794819)
|
10.5281/zenodo.7360449 |
| SH-SY5Y | EC50 |
3 μM
Compound: Carnosine
|
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
|
[PMID: 27420919] |
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1].
L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 305-84-0
-
性状 Solid
-
分子量 226.24
-
分子式 C9H14N4O3
-
Color White to off-white
-
別名
L-Carnosine
-
Structure Classification
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Redox Biol
Histidine metabolic reprogramming drives oxidative stress induced mtDNA release to promote necroptosis and airway inflammation in severe asthma. [Abstract]2026 Jun 27:95:104280. PMID: 42372708 -
Toxicol Appl Pharmacol
In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1. [Abstract]2024 May:486:116945. PMID: 38688424
溶剤 & 溶解度
H2O : 83.33 mg/mL (368.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (442.01 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74. [Content Brief]
[2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9. [Content Brief]
[3]. Jukić I, et al. Carnosine, small but mighty—prospect of use as functional ingredient for functional food formulation[J]. Antioxidants, 2021, 10(7): 1037. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4201 mL | 22.1004 mL | 44.2008 mL | 110.5021 mL |
| 5 mM | 0.8840 mL | 4.4201 mL | 8.8402 mL | 22.1004 mL | |
| 10 mM | 0.4420 mL | 2.2100 mL | 4.4201 mL | 11.0502 mL | |
| 15 mM | 0.2947 mL | 1.4734 mL | 2.9467 mL | 7.3668 mL | |
| 20 mM | 0.2210 mL | 1.1050 mL | 2.2100 mL | 5.5251 mL | |
| 25 mM | 0.1768 mL | 0.8840 mL | 1.7680 mL | 4.4201 mL | |
| 30 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6834 mL | |
| 40 mM | 0.1105 mL | 0.5525 mL | 1.1050 mL | 2.7626 mL | |
| 50 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 60 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8417 mL | |
| 80 mM | 0.0553 mL | 0.2763 mL | 0.5525 mL | 1.3813 mL | |
| 100 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Carnosine 関連分類
HY-W013494 関連分類
Powered by Bioz