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製品番号: HY-112583

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MIV-247

Name: MIV-247
Brand: MedChemExpress
SKU: HY-112583
Price: 900.00 USD
Availability: PreOrder

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

MIV-247 is a selective cathepsin S inhibitor with K_is of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1352817-76-5
分子式: C₁₇H₂₄F₃N₃O₄
分子量:391.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MIV-247 構造式

CAS 番号: 1352817-76-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MIV-247 is a selective cathepsin S inhibitor with K_is of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

IC₅₀ & Target

cathepsin S

Cathepsin アイソフォーム固有の製品をすべて表示 :

体内実験

Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1352817-76-5
分子量 391.39
分子式 C₁₇H₂₄F₃N₃O₄
SMILES

FC1(CCCC1)C[C@H](NC(C(F)(F)C)=O)C(NC2(CCC2)C(C(N)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Cell Physiol

Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis. [Abstract]

2021 Feb;236(2):1309-1320. PMID: 32657442

MIV-247 purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2021 Feb;236(2):1309-1320. [Abstract]

Western blots showing protein expression of cleaved caspase‐8, cleaved caspase‐3, and cleaved PARP in the myocardium of sham and myocardial I/R mice.

プロトコル

Animal Administration^[1]

Mice^[1]

MIV-247 is administered via oral gavage to Male C57BL/6 mice (20-30 g) at a dose volume of 5 ml/kg at doses up to 200 µmol/kg. In the PK studies, seven blood samples (20 µL) are drawn from the lateral saphenous vein of each mouse at 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, and 7 hours postdose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MIV-247

1 Cited Publications

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MIV-247 purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2021 Feb;236(2):1309-1320. [Abstract]

Customer Validation
Western blots showing protein expression of cleaved caspase‐8, cleaved caspase‐3, and cleaved PARP in the myocardium of sham and myocardial I/R mice.

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MIV-247

MedChemExpress（MCE）の使用を引用している文献 MIV-247

Cathepsin アイソフォーム固有の製品をすべて表示

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