NCX 1000
Based on 1 Customer Validation
NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.91%
- CAS 番号: 401519-96-8
- 分子式: C38H55NO10
- 分子量:685.84
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Human Endogenous Metabolite |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 401519-96-8
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性状 Solid
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分子量 685.84
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分子式 C38H55NO10
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Color White to off-white
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SMILES
C[C@H](CCC(OC1=CC=C(/C=C/C(OCCCCO[N+]([O-])=O)=O)C=C1OC)=O)[C@H]2CC[C@@]3([H])[C@]4([H])[C@@H](O)C[C@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (145.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Fiorucci S, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8897-902. Epub 2001 Jul 10. [Content Brief]
[2]. Fiorucci S, et al. NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. J Hepatol. 2003 Dec;39(6):932-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4581 mL | 7.2903 mL | 14.5807 mL | 36.4516 mL |
| 5 mM | 0.2916 mL | 1.4581 mL | 2.9161 mL | 7.2903 mL | |
| 10 mM | 0.1458 mL | 0.7290 mL | 1.4581 mL | 3.6452 mL | |
| 15 mM | 0.0972 mL | 0.4860 mL | 0.9720 mL | 2.4301 mL | |
| 20 mM | 0.0729 mL | 0.3645 mL | 0.7290 mL | 1.8226 mL | |
| 25 mM | 0.0583 mL | 0.2916 mL | 0.5832 mL | 1.4581 mL | |
| 30 mM | 0.0486 mL | 0.2430 mL | 0.4860 mL | 1.2151 mL | |
| 40 mM | 0.0365 mL | 0.1823 mL | 0.3645 mL | 0.9113 mL | |
| 50 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL | 0.7290 mL | |
| 60 mM | 0.0243 mL | 0.1215 mL | 0.2430 mL | 0.6075 mL | |
| 80 mM | 0.0182 mL | 0.0911 mL | 0.1823 mL | 0.4556 mL | |
| 100 mM | 0.0146 mL | 0.0729 mL | 0.1458 mL | 0.3645 mL |
NCX 1000 関連分類
HY-U00023 関連分類
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