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ROC-325

4 Cited Publications
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Based on 4 publication(s) in Google Scholar

ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis.

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  • 純度 : 98.73%
  • CAS 番号: 1859141-26-6
  • 分子式: C28H27ClN4OS
  • 分子量:503.06
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • ROC-325 Chemical Structure
    ROC-325 構造式
  • Experimental Validation Results for ROC-325
  • Experimental Validation Results for ROC-325
  • Experimental Validation Results for ROC-325
  • Experimental Validation Results for ROC-325
CAS 番号: 1859141-26-6
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MedChemExpress（MCE）の使用を引用している文献 ROC-325

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WBIFHistological Imaging/StainingIn Vivo Efficacy Study
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  • Histological Imaging/Staining
  • In Vivo Efficacy Study

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  • ROC-325 Chemical Structure
    ROC-325 Chemical Structure
    1/16
  • 1/16

    ROC-325 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:177007. [Abstract]

    Customer Validation
     Western blotting showed the expression of the p62, LC3A/B and GAPDH in MPCs treated with YAP siRNA or added ROC-325 with the concentration of 2.5 μM and 5 μM, respectively.

  • 1/16

    ROC-325 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:177007. [Abstract]

    Customer Validation
     Immunofluorescence staining for mRFP (red puncta) and GFP (green puncta) in the MPCs treated with ROC-325 (5 μM).

  • 1/16

    ROC-325 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:177007. [Abstract]

    Customer Validation
     Representative light microscopy of kidney sections by periodic acid–Schiff (PAS) staining from the mice treated with ROC-325 (50 mg/kg, i.g.).

  • 1/16

    ROC-325 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:177007. [Abstract]

    Customer Validation
     Representative images of the three experimental groups of mice and kidney. Body weight, kidney weight and kidney/body weight treated with ROC-325 (50 mg/kg, i.g.).

  • ROC-325