MMP Substrate

MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity.

TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm).

Mca-AQTLTL-Dpa-RSSSQ-NH2 is a fluorescent substrate peptide for TNF-α converting enzyme (TACE), with its peptide sequence spanning the TACE cleavage site of tmTNF. In its intact state, the fluorescence of Mca-AQTLTL-Dpa-RSSSQ-NH2 is quenched; upon cleavage by TACE, a fluorescent signal is released, thereby reflecting TACE enzymatic activity. Mca-AQTLTL-Dpa-RSSSQ-NH2 can be used for studies related to TACE activity and TACE inhibition.

TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm).

BHQ‑3 carboxylic acid is an azo‑containing dark fluorescence quencher. BHQ‑3 carboxylic acid is conjugated to an MMP‑cleavable peptide and paired with a fluorophore to form an activatable probe for MMP activity detection in vitro. BHQ‑3 carboxylic acid shows maximal absorption in the 620 to 730 nm range. BHQ‑3 carboxylic acid–based fluorescent probes can be used in the research of arthritis and tumor‑related pathological processes..

TG-MMP-Lys is an MMP-sensitive crosslinking peptide. TG-MMP-Lys is promising for research of fibrotic diseases (e.g., liver fibrosis).

TNO003 is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm).

TNO003 TFA is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 TFA has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 TFA can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm).