PF-06737007
Based on 1 Customer Validation
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 1863905-38-7
- 分子式: C25H28F4N2O6
- 分子量:528.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Posttranslational Modification Library
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生物活性
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TrkA 7.7 nM (IC50, in cell-based assays) |
TrkB 15 nM (IC50, in cell-based assays) |
TrkC 3.9 nM (IC50, in cell-based assays) |
化学情報
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CAS 番号 1863905-38-7
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性状 Solid
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分子量 528.49
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分子式 C25H28F4N2O6
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Color White to off-white
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SMILES
O=C(N)C1=CC=C(OCC(C)(O)C)C=C1O[C@@H]2[C@H](F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (189.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8922 mL | 9.4609 mL | 18.9218 mL | 47.3046 mL |
| 5 mM | 0.3784 mL | 1.8922 mL | 3.7844 mL | 9.4609 mL | |
| 10 mM | 0.1892 mL | 0.9461 mL | 1.8922 mL | 4.7305 mL | |
| 15 mM | 0.1261 mL | 0.6307 mL | 1.2615 mL | 3.1536 mL | |
| 20 mM | 0.0946 mL | 0.4730 mL | 0.9461 mL | 2.3652 mL | |
| 25 mM | 0.0757 mL | 0.3784 mL | 0.7569 mL | 1.8922 mL | |
| 30 mM | 0.0631 mL | 0.3154 mL | 0.6307 mL | 1.5768 mL | |
| 40 mM | 0.0473 mL | 0.2365 mL | 0.4730 mL | 1.1826 mL | |
| 50 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9461 mL | |
| 60 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7884 mL | |
| 80 mM | 0.0237 mL | 0.1183 mL | 0.2365 mL | 0.5913 mL | |
| 100 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4730 mL |
PF-06737007 関連分類
HY-112437 関連分類
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