A-1293201
Based on 1 Customer Validation
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 1375557-33-7
- 分子式: C21H23N3O3
- 分子量:365.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | IC50 |
56 nM
Compound: 58
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Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay
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[PMID: 28610984] |
| PC-3 | IC50 |
56 nM
Compound: 57; A-1293201
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Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth by Celltiter-Glo assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth by Celltiter-Glo assay
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[PMID: 38244254] |
化学情報
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CAS 番号 1375557-33-7
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性状 Solid
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分子量 365.43
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分子式 C21H23N3O3
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Color White to off-white
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SMILES
O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 62.5 mg/mL (171.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7365 mL | 13.6825 mL | 27.3650 mL | 68.4126 mL |
| 5 mM | 0.5473 mL | 2.7365 mL | 5.4730 mL | 13.6825 mL | |
| 10 mM | 0.2737 mL | 1.3683 mL | 2.7365 mL | 6.8413 mL | |
| 15 mM | 0.1824 mL | 0.9122 mL | 1.8243 mL | 4.5608 mL | |
| 20 mM | 0.1368 mL | 0.6841 mL | 1.3683 mL | 3.4206 mL | |
| 25 mM | 0.1095 mL | 0.5473 mL | 1.0946 mL | 2.7365 mL | |
| 30 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2804 mL | |
| 40 mM | 0.0684 mL | 0.3421 mL | 0.6841 mL | 1.7103 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5473 mL | 1.3683 mL | |
| 60 mM | 0.0456 mL | 0.2280 mL | 0.4561 mL | 1.1402 mL | |
| 80 mM | 0.0342 mL | 0.1710 mL | 0.3421 mL | 0.8552 mL | |
| 100 mM | 0.0274 mL | 0.1368 mL | 0.2737 mL | 0.6841 mL |
A-1293201 関連分類
HY-125147 関連分類
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