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製品番号: HY-101741

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A-259745

(別名: A-289099)

A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED₅₀ values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 256934-83-5
分子式: C₂₁H₂₂N₂O₄
分子量:366.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

A-259745 構造式

CAS 番号: 256934-83-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	ED₅₀	0.018 μM Compound: 22g	Effective dose against HCT-15 cell line. Effective dose against HCT-15 cell line.	[PMID: 11728187]
HCT-15	IC₅₀	16 nM Compound: 5b	Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15 Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15	[PMID: 11814821]
NCI-H460	ED₅₀	0.028 μM Compound: 22g	Effective dose against NCI-H460 cell line. Effective dose against NCI-H460 cell line.	[PMID: 11728187]
NCI-H460	IC₅₀	14 nM Compound: 5b	Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460 Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460	[PMID: 11814821]

化学情報

CAS 番号 256934-83-5
分子量 366.41
分子式 C₂₁H₂₂N₂O₄
SMILES

CN1C=CC2=C1C=CC(C3=NCC(C4=CC(OC)=C(OC)C(OC)=C4)O3)=C2
別名

A-289099
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Szczepankiewicz BG, et al. New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models. J Med Chem. 2001 Dec 6;44(25):4416-30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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