ABT-418
ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 147402-53-7
- 分子式: C9H14N2O
- 分子量:166.22
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | EC50 |
64 μM
Compound: 1 (ABT-418)
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Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
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[PMID: 9022806] |
| IMR-32 | EC50 |
64 μM
Compound: ABT-418
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Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
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10.1016/S0960-894X(97)10080-4 |
| PC-12 | EC50 |
214 μM
Compound: 10
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Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
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[PMID: 9435889] |
| TE-671 | EC50 |
411 μM
Compound: ABT-418
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Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
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10.1016/S0960-894X(97)10080-4 |
化学情報
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CAS 番号 147402-53-7
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分子量 166.22
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分子式 C9H14N2O
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SMILES
CN1[C@H](C2=CC(C)=NO2)CCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ABT-418 関連分類
HY-14314 関連分類
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