Agroclavine
Based on 1 Customer Validation
Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 548-42-5
- 分子式: C16H18N2
- 分子量:238.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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D1 Receptor |
α1-adrenergic receptor |
Agroclavine exhibits cytostatic activity against L5178y mouse lymphoma cells, with an EC50 value of 6.3 μM[3].
Agroclavine (0.01-0.1 μM) enhances NK cell activity and promotes the production of interleukin-2 and interferon-γ[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Agroclavine (50 μg/kg; i.p.; single dose) alters cortical and hippocampal EEG activity in healthy rats, and potentiates a robust, persistent increase in hippocampal beta2 activity (46.3% above pre-exposure levels) following combined magnetic field exposure[2].
Agroclavine (0.05-0.5 mg/kg; i.p.; single dose) at 0.5 mg/kg significantly increases splenic NK cell activity and serum CKMB levels in non-stressed normal male Wistar-Kyoto rats, while the 0.05 mg/kg dose has minimal, non-significant effects on these endpoints[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 300-360 g)[2]
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Dosage:50 μg/kg
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Administration:i.p.; single dose
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Result:Significantly increased delta (0.5-3.5 Hz) EEG activity in both the cortex and hippocampus during the first 30 minutes post-injection, with a larger effect in the cortex.
Decreased alpha (7.6-12.5 Hz) EEG activity in both the cortex and hippocampus, and decreased beta1 (12.6-17.5 Hz) activity in both regions, with a significantly greater attenuation in the cortex than the hippocampus.
Produced a significant increase in hippocampal beta2 activity, with only a non-significant trend toward increased beta2 activity in the cortex.
Potentiated an immediate, robust increase in hippocampal beta2 (22.5-30.5 Hz) activity relative to pre-exposure levels when combined with CMF exposure starting 1 hour post-injection; this effect persisted throughout the 30-minute post-exposure period, with a 46.3% increase in beta2 activity relative to pre-exposure values.
Did not produce significant changes in cortical EEG in agroclavine-pretreated rats during CMF exposure.
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Animal Model:Wistar-Kyoto (3-month-old male, 230-280 g)[3]
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Dosage:0.05 mg/kg; 0.5 mg/kg
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Administration:i.p.; single dose
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Result:Caused a moderate, non-significant increase in spleen NK cell activity at 0.05 mg/kg.
Caused a significant increase in spleen NK cell activity at 0.5 mg/kg.
Showed no significant effect on serum CKMB at 0.05 mg/kg.
Caused a significant increase in serum CKMB at 0.5 mg/kg.
Had no effect on serum ALT at both 0.05 mg/kg and 0.5 mg/kg.
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Animal Model:Wistar-Kyoto (3-month-old male, 230-280 g; restraint and immersion in 23°C water stress model)[3]
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Dosage:0.05 mg/kg; 0.5 mg/kg
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Administration:i.p.; single dose; 30 min pre-stress
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Result:Caused a significant decrease in spleen NK cell activity at 0.05 mg/kg compared to stressed control rats.
Caused a significant decrease in spleen NK cell activity at 0.5 mg/kg compared to stressed control rats.
Showed no significant effect on serum CKMB and ALT levels at 0.05 mg/kg relative to stressed controls.
Caused a more than twofold significant increase in serum CKMB at 0.5 mg/kg compared to stressed control rats.
Caused a significant increase in serum ALT at 0.5 mg/kg compared to stressed control rats.
化学情報
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CAS 番号 548-42-5
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性状 Solid
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分子量 238.33
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分子式 C16H18N2
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Color Off-white to light brown
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SMILES
CN1[C@@]2([H])[C@@](C=C(C1)C)([H])C3=CC=CC4=C3C(C2)=CN4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Vorobyov V, et al. Spatial memory deficits initiated by agroclavine injection or olfactory bulbectomy in rats are characterized by different levels of long-term potentiation expression in the hippocampus. Int J Neurosci. 2020;130(12):1225-1229. [Content Brief]
[2]. Vorobyov V, et al. Agroclavine potentiates hippocampal EEG effects of weak combined magnetic field in rats. Brain Res Bull. 2009;80(1-2):1-8. [Content Brief]
[3]. Starec M, et al. Effect of agroclavine on NK activity in vivo under normal and stress conditions in rats. Physiol Res. 2001;50(5):513-519. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Agroclavine 関連分類
HY-135525 関連分類
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