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製品番号: HY-145269

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AL-GDa62

AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1^-/- cells. AL-GDa62 has an EC₅₀ of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1^-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations.

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CAS 番号: 2761538-66-1
分子式: C₂₄H₂₈FN₃O
分子量:393.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AL-GDa62 構造式

CAS 番号: 2761538-66-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	EC₅₀	2 μM Compound: 3;AL-GDa62	Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
MCF-10A	EC₅₀	3.2 μM Compound: 3;AL-GDa62	Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
NCI-N87	EC₅₀	16.35 μM Compound: 3;AL-GDa62	Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
NCI-N87	EC₅₀	8.5 μM Compound: 3;AL-GDa62	Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]

化学情報

CAS 番号 2761538-66-1
分子量 393.50
分子式 C₂₄H₂₈FN₃O
SMILES

FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64(24):18114-18142. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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