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製品番号: HY-117376

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(all-E)-UAB30

Name: (all-E)-UAB30
Brand: MedChemExpress
SKU: HY-117376
Availability: PreOrder

(別名: UAB30)

(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 205252-59-1
分子式: C₂₀H₂₂O₂
分子量:294.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

(all-E)-UAB30 構造式

CAS 番号: 205252-59-1

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

RAR/RXR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	>2000 nM Compound: (all-E)-UAB30	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha	[PMID: 9572893]
CV-1	EC₅₀	110 nM Compound: (all-E)-UAB30	Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta	[PMID: 9572893]
CV-1	EC₅₀	370 nM Compound: (all-E)-UAB30	Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma	[PMID: 9572893]
CV-1	EC₅₀	>2000 nM Compound: (all-E)-UAB30	Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha	[PMID: 9572893]
HL-60	ED₅₀	>10000 nM Compound: (all-E)-UAB30	Induction of HL-60 cells differentiation over 4 days Induction of HL-60 cells differentiation over 4 days	[PMID: 9572893]
NB-4	ED₅₀	>10000 nM Compound: (all-E)-UAB30	Induction of NB4 cell differentiation Induction of NB4 cell differentiation	[PMID: 9572893]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

化学情報

CAS 番号 205252-59-1
分子量 294.39
分子式 C₂₀H₂₂O₂
SMILES

O=C(O)/C=C(C)/C=C/C=C(C)/C=C1CCCC2=C\1C=CC=C2
別名

UAB30
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Adele P. Williams, et al. UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts. Transl Oncol. 2019 Oct;12(10):1364-1374.

[2]. Chu-Fang Chou, et al. The Retinoid X Receptor Agonist, 9-cis UAB30, Inhibits Cutaneous T-cell Lymphoma Proliferation Through the SKP2-p27kip1 Axis. J Dermatol Sci. 2018 Jun; 90(3): 343–356.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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