Alteplase
Based on 1 Customer Validation
Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters.
The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.)
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 105857-23-6
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.)
Alteplase ( 8.3 and 250 μg/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells)[4].
Alteplase (8.3 and 250 μg/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells[4].
Product Information
This product contains L-arginine, phosphoric acid, polysorbate 80, etc. as auxiliary materials.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hfRPE cells
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Concentration:8.3 and 250 μg/mL
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Incubation Time:12 h
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Result:Decreased the number of cells that adhered to the cell culture dish, i.e., the number of living cells following treatment of hfRPE cells with 83 μg/ml alteplase for 12 h and 250 μg/ml alteplase for 6 and 12 h.
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Cell Line:hfRPE cells
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Concentration:8.3 and 250 μg/mL
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Incubation Time:0-6 h
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Result:Increased The number of positive hfRPE cells for both EthD-III and FITC-Annexin V staining.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice model of thromboembolic stroke[3]
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Dosage:0.9-10 mg/kg
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Administration:i.v., 20 to 40 minutes post ictus or 180 and 240 minutes post ictus
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Result:Significantly reduced the final infarct volume in the early stage.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
6.24×105 IU/mg protein
化学情報
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CAS 番号 105857-23-6
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性状 Solid
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Color White to off-white
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SMILES
[Alteplase]
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別名
Actilyse; Activase
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
H2O : ≥ 12.5 mg/mL
* "≥" means soluble, but saturation unknown.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. J Bastecký, et al. [Actilyse (a recombinant tissue-type plasminogen activator] in the treatment of acute myocardial infarct. Comparison of the effects of Actilyse and streptokinase]. Vnitr Lek. 1994 May;40(5):293-8. [Content Brief]
[2]. Micieli G, et al. Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag. 2009;5(1):397-409. [Content Brief]
[3]. Orset C, et al. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016 May;47(5):1312-1318. [Content Brief]
[4]. Kimura S, et al. Cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, on human retinal pigment epithelial cells. Jpn J Ophthalmol. 2021 Sep;65(5):731-739. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Alteplase 関連分類
HY-108865 関連分類
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