AMG-34
AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1644664-11-8
- 分子式: C33H27FN6O2
- 分子量:558.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
AMG-34 (0-10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, causing the most significant decrease in cell viability at intermediate concentrations (around 0.1 μM), while showing reduced inhibitory effects at both lower and higher concentrations[1].
AMG-34 (0.01-0.37 μM, 8 h) increases the expression of ATF4 in MOLM-16 cells[1].
AMG-34 (1.1-10 μM, 8 h) inhibits the expression of p-GCN2 while shows no effect on the expression of GCN2 in MOLM-16 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1644664-11-8
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分子量 558.60
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分子式 C33H27FN6O2
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SMILES
CN(N(C1=CC=CC=C1)C2=O)C(C3=CC=CC=C3)=C2C(C4=CC=C(C)C(C5=C(F)C6=CN=C(NC)N=C6C=C5)=C4N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AMG-34 関連分類
HY-175880 関連分類
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