Amquinate
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 17230-85-2
- 分子式: C18H24N2O3
- 分子量:316.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC50 of 1×10-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10-4 M[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC50 of 1×10-6 M for succinate-supported respiration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eimeria tenella[1]
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Dosage:30 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
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Animal Model:Amquinate-resistant Eimeria tenella mutant[1]
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Dosage:2000 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
化学情報
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CAS 番号 17230-85-2
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分子量 316.40
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分子式 C18H24N2O3
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SMILES
O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
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Structure Classification
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Initial Source
Mitochondria from Eimeria tenella
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Amquinate 関連分類
HY-114625 関連分類
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