Amquinate
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 17230-85-2
- 分子式: C18H24N2O3
- 分子量:316.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC50 of 1×10-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10-4 M[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC50 of 1×10-6 M for succinate-supported respiration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eimeria tenella[1]
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Dosage:30 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
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Animal Model:Amquinate-resistant Eimeria tenella mutant[1]
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Dosage:2000 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
化学情報
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CAS 番号 17230-85-2
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分子量 316.40
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分子式 C18H24N2O3
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SMILES
O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
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Structure Classification
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Initial Source
Mitochondria from Eimeria tenella
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Amquinate 関連分類
HY-114625 関連分類
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