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製品番号: HY-179228

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AN02

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.

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CAS 番号: 1246964-08-8
分子式: C₁₉H₁₅Cl₂NO
分子量:344.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AN02 構造式

CAS 番号: 1246964-08-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TGF-beta/Smad アイソフォーム固有の製品をすべて表示 :

Smad1
Smad3

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	1.6 μM Compound: A2	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay	[PMID: 38746900]
MDA-MB-468	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MG-63	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MV4-11	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H23	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H441	IC₅₀	5 μM Compound: 3	Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs	[PMID: 20638855]

化学情報

CAS 番号 1246964-08-8
分子量 344.23
分子式 C₁₉H₁₅Cl₂NO
SMILES

ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jin H, et al. AN02, a Naovel Curcumin Derivative, Orchestrates APC-SMAD4-Mediated CTLA-4 Degradation for Ovarian Cancer Therapy. Mol Carcinog. 2025 Oct 21. [Content Brief]

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AN02

TGF-beta/Smad アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AN02 関連分類

HY-179228 関連分類