ANT1034
ANT1034 is humanized anti-CD52 antibody. ANT1034 directs antibody dependent and complement dependent cell cytotoxicity, induces Apoptosis when cross-linked or in the presence of a cross-linking antibody. ANT1034 leads to increased survival in a SCID CD52 tumour xenograft model. ANT1034 can be used for the research of B cell malignancies.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Species Reactivity
Human
IC50 & Target
CD52
体外実験
ANT1034 (100 μg/ml; 72 hours) is more effective at directly inducing cell death (apoptosis/necrosis) in REH++ cells than Alemtuzumab (HY-P9948) in the presence of a crosslinking antibody[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fox Chase SCID mice (female, 8 per group, injected with 1×10⁶ Raji++ cells via tail-vein injection)[1]
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Dosage:1, 10 mg/kg
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Administration:i.p.; once daily on alternate days; 7 doses
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Result:Increased mouse survival compared to alemtuzumab at 10 mg/kg; Showed superior survival enhancement even at the lower 1 mg/kg dose relative to alemtuzumab
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Splenic/Portal-Vein Liver Metastasis Xenograft
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Cell Viability Determination by MTT Colorimetric Assay
- Intraperitoneal/Peritoneal Dissemination Xenograft
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
化学情報
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ANT1034 関連分類
HY-P991935 関連分類
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Keywords
- ANT1034
- ANT 1034
- ANT-1034
- Apoptosis
- CD4? T cell proliferation
- Raji Burkitt lymphoma xenograft
- apoptosis
- b cell malignancies
- SCID mouse/human CD52 tumour xenograft model
- complement dependent cell cytotoxicity
- T cell proliferation
- REH++ cells
- cancer
- Fox Chase SCID mice
- antibody dependent cell cytotoxicity
- crosslinking antibody
- human peripheral blood mononuclear cells
- alemtuzumab
- CD52
- Inhibitor
- inhibitor
- inhibit