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製品番号: HY-162311

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Anticancer agent 194

Name: Anticancer agent 194
Brand: MedChemExpress
SKU: HY-162311
Availability: PreOrder

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS.

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CAS 番号: 2767204-90-8
分子式: C₁₂H₁₆ClN₃O₂
分子量:269.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Anticancer agent 194 構造式

CAS 番号: 2767204-90-8

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	6.18 μM Compound: 10p	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
HepG2	IC₅₀	13.79 μM Compound: 10p	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
HT-29	IC₅₀	1.97 μM Compound: 10p	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
K562	IC₅₀	4.92 μM Compound: 10p	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
MCF7	IC₅₀	7.01 μM Compound: 10p	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]

体外実験

Anticancer agent 194 (compound 10p; 1-10 μM; 48 h) presents antiproliferative activity against HT-29 cancer cells with an IC50 of 1.97 μM^[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) arrests cell cycle at G2/M phase in a concentration-dependent manner^[1].
Anticancer agent 194 (compound 10p; 0.5-4 μM; 48 h) decreases the expression of GPX4 in a concentration-dependent manner^[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) induces HT-29 cells autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 5 μM and 10 μM
Incubation Time:

48 h
Result:

Induced cell death.

Cell Cycle Analysis^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Arrested cell cycle at G2/M phase.

Western Blot Analysis^[1]

Cell Line:

HT-29 cells
Concentration:

0.5 μM, 1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Decreased the expression of GPX4 in a concentration-dependent manner.

Cell Autophagy Assay^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Induced autophagy of HT-29 cells.

Related Protocols :

化学情報

CAS 番号 2767204-90-8
分子量 269.73
分子式 C₁₂H₁₆ClN₃O₂
SMILES

O=C(NCCCl)N1C2=CC=C(OC)C=C2NCC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Gastroenterol

2026 Aug 20. PMID: 42622824

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tingting Liang, et al. Discovery of novel urea derivatives as ferroptosis and autophagy inducer for human colon cancer treatment. Eur J Med Chem. 2024 Feb 24:268:116277. [Content Brief]

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Anticancer agent 194

1 Cited Publications

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Publications (1)
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Anticancer agent 194

MedChemExpress（MCE）の使用を引用している文献 Anticancer agent 194

生物活性

製品説明

Cellular Effect

体外実験

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Anticancer agent 194

MedChemExpress（MCE）の使用を引用している文献 Anticancer agent 194

生物活性

製品説明

Cellular Effect

体外実験

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs