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製品番号: HY-162311

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Anticancer agent 194

Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2767204-90-8
分子式: C₁₂H₁₆ClN₃O₂
分子量:269.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Anticancer agent 194 構造式

CAS 番号: 2767204-90-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	6.18 μM Compound: 10p	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
HepG2	IC₅₀	13.79 μM Compound: 10p	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
HT-29	IC₅₀	1.97 μM Compound: 10p	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
K562	IC₅₀	4.92 μM Compound: 10p	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
MCF7	IC₅₀	7.01 μM Compound: 10p	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]

体外実験

Anticancer agent 194 (compound 10p; 1-10 μM; 48 h) presents antiproliferative activity against HT-29 cancer cells with an IC50 of 1.97 μM^[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) arrests cell cycle at G2/M phase in a concentration-dependent manner^[1].
Anticancer agent 194 (compound 10p; 0.5-4 μM; 48 h) decreases the expression of GPX4 in a concentration-dependent manner^[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) induces HT-29 cells autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 5 μM and 10 μM
Incubation Time:

48 h
Result:

Induced cell death.

Cell Cycle Analysis^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Arrested cell cycle at G2/M phase.

Western Blot Analysis^[1]

Cell Line:

HT-29 cells
Concentration:

0.5 μM, 1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Decreased the expression of GPX4 in a concentration-dependent manner.

Cell Autophagy Assay^[1]

Cell Line:

HT-29 cells
Concentration:

1 μM, 2 μM and 4 μM
Incubation Time:

48 h
Result:

Induced autophagy of HT-29 cells.

化学情報

CAS 番号 2767204-90-8
分子量 269.73
分子式 C₁₂H₁₆ClN₃O₂
SMILES

O=C(NCCCl)N1C2=CC=C(OC)C=C2NCC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tingting Liang, et al. Discovery of novel urea derivatives as ferroptosis and autophagy inducer for human colon cancer treatment. Eur J Med Chem. 2024 Feb 24:268:116277. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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