Anticancer agent 207
Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C29H39FN4O2
- 分子量:494.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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NRAS rG4 2.31 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
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| A-375 | IC50 |
4.5 μM
Compound: 10b
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Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay
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[PMID: 38688064] |
| HepG2 | IC50 |
1.5 μM
Compound: 10b
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Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay
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[PMID: 38688064] |
| HL-60 | IC50 |
2.7 μM
Compound: 10b
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Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay
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[PMID: 38688064] |
| MCF7 | IC50 |
4.1 μM
Compound: 10b
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Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
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[PMID: 38688064] |
| SK-MEL-2 | IC50 |
2 μM
Compound: 10b
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Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay
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[PMID: 38688064] |
Anticancer agent 207 (48 h) shows cytotoxicity for NRAS-mutant melanoma SK-MEL-2 with an IC50 value of 2.0 µM[1].
Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) decreases the expression of NRAS protein[1].
Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) inhibits the colony formation of SK-MEL-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-2 cells
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Concentration:0, 0.5, 1.0 µM
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Incubation Time:72 h
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Result:Decreased the expression of NRAS protein in a dose-dependent manner.
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Cell Line:MCF-7, HepG2, HL60, A375 cells
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Concentration:0-100 µM
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Incubation Time:48 h
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Result:Showed cytotoxicity with IC50s of 4.1, 1.5, 2.7, 4.5 µM for MCF-7, HepG2, HL60, A375 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old male BALB/C nude mice (SK-MEL-2 xenograft mouse model)[1]
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Dosage:1 mg/kg
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Administration:I.p.; every day for 21 days
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Result:Suppressed tumor growth in volume and weight in the xenograft mouse model time-dependently.
化学情報
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分子量 494.64
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分子式 C29H39FN4O2
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SMILES
CCCCN(CCCOC1=CC=C2N=C3C4=C(OC3=C(C2=C1)NCCCN)C=CC(F)=C4)CCCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 207 関連分類
HY-163515 関連分類
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