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製品番号: HY-146396

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Anticancer agent 51

Anticancer agent 51 (compound 3d) is a potent anticancer agent with an K_i of 731.62 nM. Anticancer agent 51 shows anticancer activity. Anticancer agent 51 has the potential for the research of prostate cancer.

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CAS 番号: 2521777-38-6
分子式: C₂₂H₂₀F₃N₃O₂S
分子量:447.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Anticancer agent 51 構造式

CAS 番号: 2521777-38-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MetAP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	62.2 μM Compound: 3d; SGK-606	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]
LNCaP	IC₅₀	92.8 μM Compound: 3d; SGK-606	Cytotoxicity against human LNCaP cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human LNCaP cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]
PC-3	IC₅₀	64.3 μM Compound: 3d; SGK-606	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]

体外実験

Anticancer agent 51 (compound 3d) shows anticancer activity with IC₅₀s of 64.3, 62.2, 92.8 μM for PC-3, DU-145, LNCaP cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2521777-38-6
分子量 447.47
分子式 C₂₂H₂₀F₃N₃O₂S
SMILES

FC(F)(F)C(C=C1)=CC=C1NC(NNC([C@H](C2=CC3=C(C=C2)C=C(C=C3)OC)C)=O)=S
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Birgül K, et al. Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives. Eur J Med Chem. 2020 Dec 15;208:112841. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anticancer agent 51

MetAP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Anticancer agent 51 関連分類

HY-146396 関連分類