country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-151426

Copy Link Print Information

Anticancer agent 83

Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI₅₀ value of 0.15 mM. Anticancer agent 83 reduces mitochondrial membrane potential and induces DNA damage to induces leukemia cells apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 904815-29-8
分子式: C₂₀H₁₉N₅OS
分子量:377.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 83 構造式

CAS 番号: 904815-29-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human A549 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
BALB/3T3	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HaCaT	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human HaCaT cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HaCaT cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HCT-116	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HCT-116	GI₅₀	8.4 μM Compound: 4a	Antiproliferative activity against p53-deficient human HCT-116 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against p53-deficient human HCT-116 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HEK293	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human HEK293 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HEK293 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HeLa	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human HeLa cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HL-60(TB)	GI₅₀	2.8 μM Compound: 4a	Antiproliferative activity against human HL-60(TB) cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human HL-60(TB) cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
HOP-92	GI₅₀	2.85 μM Compound: 4a	Antiproliferative activity against human HOP-92 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human HOP-92 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
Jurkat	GI₅₀	0.69 μM Compound: 4a	Antiproliferative activity against human Jurkat cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human Jurkat cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
K562	GI₅₀	5.4 μM Compound: 4a	Antiproliferative activity against human K562 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human K562 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
KB 3-1	GI₅₀	7.4 μM Compound: 4a	Antiproliferative activity against human KB 3-1 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human KB 3-1 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
LOX IMVI	GI₅₀	0.15 μM Compound: 4a	Antiproliferative activity against human LOX IMVI cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human LOX IMVI cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
MCF7	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human MCF7 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
MDA-MB-231	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
NCI-H460	IC₅₀	28 nM Compound: 4a	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
NCI-H522	GI₅₀	1.97 μM Compound: 4a	Antiproliferative activity against human NCI-H522 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human NCI-H522 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
RXF 393	GI₅₀	4.27 μM Compound: 4a	Antiproliferative activity against human RXF 393 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human RXF 393 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
SF-295	GI₅₀	2.71 μM Compound: 4a	Antiproliferative activity against human SF-295 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human SF-295 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
SK-OV-3	GI₅₀	10 μM Compound: 4a	Antiproliferative activity against human SK-OV-3 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human SK-OV-3 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
SR	GI₅₀	1.77 μM Compound: 4a	Antiproliferative activity against human SR cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human SR cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
THP-1	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human THP-1 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human THP-1 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
TK-10	GI₅₀	3.21 μM Compound: 4a	Antiproliferative activity against human TK-10 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human TK-10 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
UO-31	GI₅₀	2.88 μM Compound: 4a	Antiproliferative activity against human UO-31 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human UO-31 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
WM793	GI₅₀	>100 μM Compound: 4a	Antiproliferative activity against human WM793 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human WM793 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]

体外実験

Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human colon carcinoma HCT116 p53^−/− cells with deletion of P53 gene (GI₅₀=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI₅₀=7.4 μM), human ovarian carcinoma Skov 3 cells (GI₅₀=10 μM), and human chronic myelogenous leukemia K562 cells (GI₅₀=5.4 μM)^[1].
Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases mitochondrial membrane potential^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human colon carcinoma HCT116 p53−/− cells with deletion of P53 gene, human epidermoid cervix carcinoma KB3-1, human ovarian carcinoma Skov 3 cells, and human chronic myelogenous leukemia K562 cells
Concentration:

0.01, 0.1, 1, 10, 100 μM
Incubation Time:

24 hours
Result:

Inhibited cell viability in different cells with GI₅₀s of 8.4 M (HCT116 p53^−/−), 7.4 M (KB3-1), 10 M (Skov 3), and 5.4 M (K562), respectively.

Immunofluorescence^[1]

Cell Line:

Jurkat cells
Concentration:

0.5 μM
Incubation Time:

24 hours
Result:

Induced morphological changes (including apoptotic bodies, membrane blebbing, chromatin condensation), and DNA fragmentation in Jurkat T-cells.

化学情報

CAS 番号 904815-29-8
分子量 377.46
分子式 C₂₀H₁₉N₅OS
SMILES

O=C(C1=C(C)N(C2=CC=C(C(C)C)C=C2)N=N1)NC3=CC=C(SC#N)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pokhodylo N, et al. Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells. Eur J Med Chem. 2022 Nov 5;241:114633. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ