Antimalarial agent 25
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo.
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- CAS 番号: 2944456-41-9
- 分子式: C21H18N4O3
- 分子量:374.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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- 純度とドキュメンテーション
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
289.2 μM
Compound: 8
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Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
| Vero | CC50 |
400.6 μM
Compound: 8
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Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
体外実験
Antimalarial agent 25 (compound 8) inhibits P. falciparum with IC50 of 4.2 μM, while shows CC50 on mammalian cells with CC50s of 289.2 μM (HepG2), and 400.6 μM (Vero), respectively[1].
Antimalarial agent 25 (compound 8) (15.62-1000 μM; 2 h) shows hemolytic activity below 40% at concentrations from 15.6 to 250 μM in uninfected human erythrocytes[1].
Antimalarial agent 25 (compound 8) (30-0.411 μg/mL; 48 h) causes morphological changes such as complete cytoplasmic degradation and loss of membrane integrity in the W2 strain of P. falciparum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:W2 strain of P. falciparum (CQ-resistant)
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Concentration:30 - 0.411 μg/mL
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Incubation Time:48 h
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Result:Presented completely degraded cytoplasm with loss of membrane integrity, dense cytoplasm with some possible undefined organelles in degenerating stage, and a possible deteriorated food vacuole.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice infected with Plasmodium berghei ANKA[1]
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Dosage:30 mg/kg
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Administration:Oral administration; for 4 consecutive days
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Result:Partly reduced P. berghei infection.
Parasitemia decreased by 33% on the seventh day (post-treatment).
化学情報
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CAS 番号 2944456-41-9
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分子量 374.39
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分子式 C21H18N4O3
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SMILES
COC1=CC=C(C=C1)C2=CN(N=N2)CCNC3=CC(C4=CC=CC=C4C3=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 25 関連分類
HY-149938 関連分類
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