APL-1082
Based on 1 Customer Validation
APL-1082 is a drug-Linker conjugate that can be used for ADC synthesis. APL-1082 contains Exatecan (HY-13631) and Linker (HY-175929). APL-1082 reduces aggregation and hydrophobicity in Trastuzumab (HY-P9907) ADCs, enables production of high-DAR (10) ADCs with homogeneity and defined physicochemical properties. APL-1082 forms a Trastuzumab ADC with enhanced stability, showing greater DAR retention over time. APL-1082 can be used for the research of gastric cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.58%
- CAS 番号: 2921735-93-3
- 分子式: C60H70FN11O16
- 分子量:1220.26
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
APL-1082 conjugated Trastuzumab (DAR = 8) has higher hydrophilicity, shorter HIC retention time, and lower aggregation rate than Trastuzumab-deruxtecan (HY-138298A)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.CB17 homozygous mice (5 × 106 NCI-N87 cells was injected into the right hind flank for a xenograft model)[1]
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Dosage:1.25 mg/kg conjugated with Trastuzumab; 2.5 mg/kg conjugated with Trastuzumab
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Administration:tail vein injection; 4 doses on days 0, 4, 7, and 11
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Result:Inhibited tumor growth.
化学情報
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CAS 番号 2921735-93-3
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性状 Solid
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分子量 1220.26
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分子式 C60H70FN11O16
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Color Light yellow to yellow
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SMILES
O=C(C=CC1=O)N1CCCCCNC(C(C2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)OC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O
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別名
Mc-exo-EVC-Exatecan
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (81.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8195 mL | 4.0975 mL | 8.1950 mL | 20.4874 mL |
| 5 mM | 0.1639 mL | 0.8195 mL | 1.6390 mL | 4.0975 mL | |
| 10 mM | 0.0819 mL | 0.4097 mL | 0.8195 mL | 2.0487 mL | |
| 15 mM | 0.0546 mL | 0.2732 mL | 0.5463 mL | 1.3658 mL | |
| 20 mM | 0.0410 mL | 0.2049 mL | 0.4097 mL | 1.0244 mL | |
| 25 mM | 0.0328 mL | 0.1639 mL | 0.3278 mL | 0.8195 mL | |
| 30 mM | 0.0273 mL | 0.1366 mL | 0.2732 mL | 0.6829 mL | |
| 40 mM | 0.0205 mL | 0.1024 mL | 0.2049 mL | 0.5122 mL | |
| 50 mM | 0.0164 mL | 0.0819 mL | 0.1639 mL | 0.4097 mL | |
| 60 mM | 0.0137 mL | 0.0683 mL | 0.1366 mL | 0.3415 mL | |
| 80 mM | 0.0102 mL | 0.0512 mL | 0.1024 mL | 0.2561 mL |
APL-1082 関連分類
HY-175888 関連分類
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