Arazine
Based on 1 Customer Validation
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.4%
- CAS 番号: 135304-07-3
- 分子式: C20H33NO3S
- 分子量:367.55
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1]. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TPA-induced ear acute inflammation in mouse[1]
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Dosage:2000 μg/20 μl
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Administration:2000 μg/20 μl; Applied on ear
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Result:Inhibited ear edema, as measured by ear weight.
化学情報
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CAS 番号 135304-07-3
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性状 Liquid
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分子量 367.55
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分子式 C20H33NO3S
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Color Colorless to light yellow
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SMILES
O=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O
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別名
N-Acetyl-S-farnesyl-L-cysteine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
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データシート (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gordon JS, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.J Invest Dermatol. 2008 Mar;128(3):643-54. Epub 2007 Sep 20. [Content Brief]
[2]. Adhami K, et al. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells.Exp Dermatol. 2012 Sep;21(9):700-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Arazine 関連分類
HY-133021 関連分類
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