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製品番号: HY-165466

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Azidothiorphan

Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a K_i value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 83960-29-6
分子式: C₁₂H₁₄N₄O₃S
分子量:294.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azidothiorphan 構造式

CAS 番号: 83960-29-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Azidothiorphan (100 nM; 5 minutes) irreversibly inhibits enkephalinase from mouse striatal membranes (P₂ fraction) with 98% activity loss at 100 nM after 5 minutes of 254 nm irradiation^[1].
Azidothiorphan potently inhibits purified neutral endopeptidase 24.11 with a K_i of 0.75 nM and acts as an active-site-directed irreversible photoaffinity ligand for the enzyme^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Azidothiorphan (50 μg/mouse; intracerebroventricular injection) produces a long-lasting analgesic effect in mice, which does not disappear until 6 h later^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 83960-29-6
分子量 294.33
分子式 C₁₂H₁₄N₄O₃S
SMILES

[N-]=[N+]=NC1=CC=C(C=C1)CC(C(=O)NCC(=O)O)CS
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Roques BP, et al. New enkephalinase inhibitors as probes to differentiate "enkephalinase" and angiotensin-converting-enzyme active sites. Life Sci. 1982 Oct 18-25;31(16-17):1749-52. [Content Brief]

[2]. Beaumont A, et al. Irreversible photolabeling of active site of neutral endopeptidase-24.11 "enkephalinase" by azidothiorphan and [14C]-azidothiorphan. Molecular pharmacology. 1987 Nov;32(5):594-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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