B-355252
Based on 1 publication(s) in Google Scholar
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.71%
- CAS 番号: 1261576-81-1
- 分子式: C25H24ClN3O3S2
- 分子量:514.06
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 B-355252
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生物活性
化学情報
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CAS 番号 1261576-81-1
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性状 Solid
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分子量 514.06
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分子式 C25H24ClN3O3S2
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Color White to off-white
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SMILES
O=S(C1=CC(Cl)=C(S1)OC2=CC=CC(N3CCNCC3)=C2)(NCC4=C5C=CC=CC5=CC=C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
CCAAT/enhancer binding protein beta (C/EBPβ) regulates the formation of the ovarian reserve. [Abstract]2025 Sep 30;8(1):1394. PMID: 41028284
溶剤 & 溶解度
DMSO : 30 mg/mL (58.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (421 KB)
- English - EN (421 KB)
- Français - FR (421 KB)
- Deutsch - DE (421 KB)
- Norwegian - NO (421 KB)
- Español - ES (421 KB)
- Swedish - SV (421 KB)
- Italian - IT (421 KB)
- Portuguese - PT (421 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9453 mL | 9.7265 mL | 19.4530 mL | 48.6325 mL |
| 5 mM | 0.3891 mL | 1.9453 mL | 3.8906 mL | 9.7265 mL | |
| 10 mM | 0.1945 mL | 0.9726 mL | 1.9453 mL | 4.8632 mL | |
| 15 mM | 0.1297 mL | 0.6484 mL | 1.2969 mL | 3.2422 mL | |
| 20 mM | 0.0973 mL | 0.4863 mL | 0.9726 mL | 2.4316 mL | |
| 25 mM | 0.0778 mL | 0.3891 mL | 0.7781 mL | 1.9453 mL | |
| 30 mM | 0.0648 mL | 0.3242 mL | 0.6484 mL | 1.6211 mL | |
| 40 mM | 0.0486 mL | 0.2432 mL | 0.4863 mL | 1.2158 mL | |
| 50 mM | 0.0389 mL | 0.1945 mL | 0.3891 mL | 0.9726 mL |
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