BAP2

BAP2 (1 h) potently inhibits the reductase activity of recombinant wild-type PDI, with an IC₅₀ of 0.85 μM^[1].
BAP2 binds to recombinant wild-type PDI, with a K_d value of 9.1 μM as determined by isothermal titration calorimetry^[1].
BAP2 moderately inhibits the viability of U87MG, A172 and NU04 glioblastoma cells, with IC₅₀ values ranging from 10.3 μM to 16.8 μM; it is 5.8 times more potent against NU04 cells compared with normal HFF-1 fibroblasts^[1].
BAP2 (20 μM; 2-24 h) induces endoplasmic reticulum stress in U87MG and A172 glioblastoma cells via the expression level of GRP78, without altering the level of PDI^[1].
BAP2 (10-30 μM; 24 h) inhibits the migration of A172 glioblastoma cells in wound healing assays^[1].
BAP2 (1 μM; 10-12 days) acts synergistically with ionizing radiation to reduce the clonogenic survival rate of D54 glioblastoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.