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Batoclimab

(別名: RVT-1401; HBM9161; IMVT-1401)
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Based on 1 Customer Validation

Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.89%
  • CAS 番号: 2187430-05-1
  • 分子量:143.43 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Batoclimab
  • Experimental Validation Results for Batoclimab
  • Experimental Validation Results for Batoclimab
  • Batoclimab Chemical Structure
    Batoclimab 構造式
CAS 番号: 2187430-05-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda2

  • 1/16

    Immobilized FCRN-B2M Protein, Human (HEK293, His, HY-P70601) can bind Batoclimab. The EC50 for this effect is 97.79 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Batoclimab (HY-P99009, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2, Isotype Control (HY-P990096) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Batoclimab Chemical Structure
    1/16
  • Batoclimab
  • Immobilized FCRN-B2M Protein, Human (HEK293, His, HY-P70601) can bind Batoclimab. The EC50 for this effect is 97.79 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Batoclimab (HY-P99009, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2, Isotype Control (HY-P990096) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Human IgG1 lambda2