BChE-IN-13
BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2700896-73-5
- 分子式: C24H28N2O
- 分子量:360.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.22 μM (eqBChE) 0.016 μM (hBChE)[1]
BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells[1].
BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y, PC12, BV2 and HT-22 cells
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Concentration:5-100 μM
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Incubation Time:24 hours
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Result:Showed cells viability more than 60% of SH-SY5Y, PC-12 and HT-22 even at 100 μM. Showed high mortality in BV2 cells, and reached half the mortality at 20 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
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Dosage:15 mg/kg
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Administration:Oral gavage; 15 mg/kg; once daily; 6 days
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Result:Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
化学情報
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CAS 番号 2700896-73-5
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分子量 360.49
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分子式 C24H28N2O
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SMILES
O=C(NC1=CC=CC=C1C)CN(CC(C)C)CC2=CC=C3C=CC=CC3=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE-IN-13 関連分類
HY-151386 関連分類
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