BChE-IN-14
BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2700896-78-0
- 分子式: C24H29N
- 分子量:331.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 0.23 μM (eqBChE), 0.011 μM (hBChE)[1]
体外実験
BChE-IN-14 (0.0001-100 μM) inhibits eqBChE from house serum and hBChE with IC50s of 0.23 and 0.011 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice with oligomerized Aβ1-42 peptide injection[1]
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Dosage:15 mg/kg
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Administration:Oral gavage; 15 mg/kg for Aβ1-42 injection days 3-8
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Result:Improved memory and cognitive function in vivo and showed a shorter latency than donepezil.
化学情報
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CAS 番号 2700896-78-0
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分子量 331.49
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分子式 C24H29N
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SMILES
CCCCN(CC1=CC=C2C=CC=CC2=C1)CCCC3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE-IN-14 関連分類
HY-151389 関連分類
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