BChE-IN-8
BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2653349-78-9
- 分子式: C18H12BrN7O2
- 分子量:438.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 0.15 ± 0.10 nM (eqBChE), 45.2 ± 45.0 nM (hBChE) [1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
27.84 μM
Compound: 20
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Cytotoxicity against mouse BV-2 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 35728508] |
化学情報
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CAS 番号 2653349-78-9
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分子量 438.24
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分子式 C18H12BrN7O2
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SMILES
O=C(NC1=CC(C#N)=CC(Br)=C1)CN2C3=CC=CC=C3N=C2C4=NON=C4N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE-IN-8 関連分類
HY-147859 関連分類
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